MicroRNAs as Possible Biomarkers for Breast Cancer in Samples of Iraqi and British Women

This book is aimed to determine the expression of microRNA molecules as early prognosis biomarkers for the detection of breast cancer. To achieve this project, a total of fifteen serum samples were collected from Iraqi women with breast cancer and from six serum samples which were collected from healthy women volunteers as a control group. In these samples, levels of estrogen and progesterone hormones and cancer antigen 15-3 (CA15-3) marker were determined to study the relationship between these parameters and breast cancer in Iraqi women. Results showed that there is a significant negative correlation (r2=¯0.4) between the level of serum estrogen hormone and the age of breast cancer patients, while there is no significant correlation between the level of progesterone hormone and the age of the patients, as well as no significant correlation between the level of CA15-3 marker and patients age in comparison with healthy controls which means that estrogen hormone level was decreased with the age of patients. In conclusion, the results indicated that there is a possibility of detecting the changes in the level of microRNAs expression as useful biomarkers for the detection and early diagnosis of breast cancer. Read more